Studies on Alloxan
نویسندگان
چکیده
منابع مشابه
Studies on the mechanism of alloxan hypoglycemia.
It is well known that when alloxan is injected intravenously into rabbits, dogs, and monkeys an initial hyperglycemia is followed by a transient hypoglycemia, leading to death of the animals from hypoglycemic convulsions. If the hypoglycemia is prevented by repeated intravenous injections of glucose, the animals survive and permanent hyperglycemia and diabetes develop. The cause of the transien...
متن کاملStudies on the Relationship of Alloxan-diabetes
A reduction in the size and incidence of tumors has been shown to occur in alloxanized Wistar rats given injections intraperi@oneally of homogenates of the transplantable Novikoff hepatoma (9, 10). Salzberg and Griffin (@6)likewise demonstrated a reduction in the incidence of DAB-induced hepa tomas in alloxanized rats, and Vangerov and Mc Kee (80) have recently reported a diminution in the grow...
متن کاملEnzymic studies on the lenses of alloxan-diabetic rats.
The accumulation of sorbitol has been described as one of the causative factors of the diabetic cataract (Kinoshita, 1974; Dvornik et al., 1973), and hyperglycaemia seems to have a potentiating effect on the formation of the senile type of cataract. Pirie & van Heyningen (1964) found that, in the cataractous lenses of the diabetic patients, more glucose and fructose accumulated than in non-diab...
متن کاملStudies on Glycogen Nephrosis in Alloxan-treated Diabetic Rats
Two hundred and seven albino rats were injected subcutaneously with alloxan in doses varying from 140 to 200 mg. per cent per kilo of body weight. Fifty-nine animals which developed hyperglycemia (blood sugar levels above 150 mg. per cent) were observed for periods from 5 days to 32 weeks. Postmortem examination of the kidneys of these diabetic animals revealed glycogen deposition in the loops ...
متن کاملBiochemical studies on hypoglycemic effect of Aavirai kudineer: a herbal formulation in alloxan diabetic rats.
Aavirai Kudineer (AK) is an herbal decoction of seven botanical drugs, cited in the Gunapadam; a Tamil Siddha medical text. The anti-diabetic efficacy of this formulation was evaluated using alloxan-induced diabetic and normal rats. Glucose tolerance was observed within 1 hr in AK-treated rats (10 ml/kg body ) as compared to control. A significant decrease in the severe hyperglycemia characteri...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1964
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)51780-4